Product name:CHO-PEG-CHO

Product specification:1g、500mg( Customized according to requirements）

PEG molecular weight：1K,2K, 5K, 10K, 20K, 40K

Product description:

CAS NO.:--

Molecular formula：--

 Appearance：Solid powder,white

Common solvents：dissolve in DMF,DCM,water

Reminder：In order to obtain the best use effect of the product, the material should always be kept at a low temperature under dry conditions to avoid frequent thawing and freezing. 

In order to ensure the stability of the product, please note that the package can only be opened after constant temperature drying!

Aldehyde peg is an amine reactive peg derivative, which can be used to modify biomolecules through available amine groups. Of aldehyde and lysine residues ε- Amine and N-terminal α- The reaction between amines produces an intermediate Schiff base. Further reduction with hydride will form a stable CN bond. Peg aldehyde reacts with amine group at pH of 5.5 to 9.5. Higher pH value will lead to multiple PEGylation of terminal and lysine groups. Aldehyde peg is a common peg reagent for PEGylation of N-terminal in proteins or peptides.

Dissolve the target substance in PEGylation buffer, estimate the concentration of primary amine group on the target material, add peg aldehyde stock solution to the target conjugate, maintain the final concentration at least 10 mg / ml, and stir the mixture at room temperature for 2 to 4 hours, or overnight at room temperature 4 ℃. After reaction, the C = n bond can be reduced by sodium borohydride, and the conjugate can be purified by size exclusion chromatography or dialysis.