为华生物COOH-PEG-COOH聚乙二醇二羧酸的简介及应用说明

COOH-PEG-COOH聚乙二醇二羧酸结构式：

COOH-PEG-COOH聚乙二醇二羧酸是官能化的聚乙二醇（cooh-peg-cooh），是一种双功能PEG衍生物。COOH-PEG-COOH聚乙二醇二羧酸PH值：2.1 (100g/l, H2O)，闪点：华氏：572 °F摄氏：300 °C，密度：1.191 g/mL at 25 °C

COOH-PEG-COOH是一类同双官能团修饰剂，可用于修饰蛋白质、氨基或其他酸反应的化学基团的肽和其他材料。可用于靶向药物研究并广泛应用于蛋白载体及配基的交联等。PEG末端的羟端基被羧基取代，主要强调利用羧基和羟基发生酯化反应形成酯键,与氨基发生的亲和取代反应形成酰胺等的羧基特性，从而有效地将PEG链接到所需材料或小分子药物及多肽上去，以达到反应的目的。

COOH-PEG-COOH is a kind of bifunctional modifier, which can be used to modify peptides and other materials of proteins, amino groups or other acid reaction chemical groups. It can be used in targeted drug research and widely used in protein carriers and cross-linking of ligands. The hydroxyl terminal group at the end of PEG is replaced by carboxyl group, which mainly emphasizes the carboxyl group characteristics of ester bond formed by esterification reaction between carboxyl group and hydroxyl group, and amide formed by affinity substitution reaction with amino group, so as to effectively link peg to the required materials or small molecule drugs and polypeptides to achieve the purpose of reaction.

PEG修饰可提高溶解度和稳定性，减少蛋白质和肽的免疫原性。它也可以抑制电荷的分子改性表面的非特异性结合。

注意事项：材料COOH-PEG-COOH聚乙二醇二羧酸易吸潮，取用前需放置室温后再打开包装取用防止吸潮，吸潮后活性会降低直至完全失去活性，请务必保持干燥，同时尽量避免频繁的溶解和冻干。

类似化合物：

NH2-PEG-NH2聚乙二醇二胺

NHS-PEG-NHS双琥珀酰亚胺酯聚乙二醇

CHO-PEG-CHO双醛基聚乙二醇

SH-PEG-SH 巯基聚乙二醇巯基

MAL-PEG-MAL 聚乙二醇双马来酰亚胺